Maps & Directions
 Orangeburg County is strategically located between the state capital of Columbia and the port of Charleston. We invite you to enjoy our wonderful location and natural beauty that has much to offer!
Did you know Orangeburg County has access to 8 US Highways?
US 21, US 78, US178, US 176, US 301, US 321, US 601
From Columbia
Take I-26 toward Charleston
Take Exit 145-A to Orangeburg which is US 601 & St. Matthews Road
It will change to Magnolia Street after coming into the city (approximately 5 miles)
After passing Claflin University & South Carolina University, turn right at the
traffic light at McDonalds as US 601 joins US 301 (John C. Calhoun Drive)
Follow John C. Calhoun Drive for approximately 10 blocks
Turn right onto Riverside Drive at the sign for Edisto Memorial Gardens
The Chamber is the first building on the left
From Charleston
Take I-26 W toward Columbia
Take Exit 154-A to Orangeburg which is US 301
Follow US 301 into the city (about 7-8 miles)
At the 9th traffic light turn right at Riverside Drive
The Chamber is located at the entrance of the Edisto Memorial Gardens
From I-95 North
Take I-26 W Exit 86B toward Columbia
Take Exit 154-A to Orangeburg
Follow Highway 301 into Orangeburg (about 7-8 miles)
Follow US 301 into the city (about 7-8 miles)
At the 9th traffic light turn right at Riverside Drive
The Chamber is located at the entrance of the Edisto Memorial Gardens
From I-95 South
Take Exit 97 toward Orangeburg
That will put you on Highway 301
Follow Highway 301 into Orangeburg (about 7-8 miles)
Follow US 301 into the city (about 7-8 miles)
At the 9th traffic light turn right at Riverside Drive
The Chamber is located at the entrance of the Edisto Memorial Gardens
Map to Orangeburg Chamber of Commerce
Map to Orangeburg Chamber of Commerce
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